Introduction
Dermatopathology laboratories process some of the highest specimen volumes in diagnostic medicine. From routine skin biopsies to complex immunohistochemical cases, every step from accessioning to final diagnosis demands accuracy, consistency, and speed.
A Dermatopathology Laboratory Information System (LIS) is the backbone of these operations. It centralizes workflows, automates repetitive tasks, and ensures that every specimen, image, slide, and report is traceable at all stages.
This guide explains what a dermatopathology LIS is, why it matters, how it supports modern labs, and what features truly make a difference.
What Makes Dermatopathology Different From Other Pathology Specialties?
Dermatopathology presents several unique challenges:
- High volume of small, similar-looking specimens
- Frequent multiple-part biopsies
- Need for precise site labeling (e.g., “left forearm dorsal”)
- Heavy reliance on microscopy and digital imaging
- Large number of routine but time-sensitive diagnoses
- Complex reporting with micro/macro descriptions
- Regular use of IHC and special stains
A traditional, generic LIS often struggles to manage these dermatopathology-specific workflows leading to manual steps, errors, and delays.
This is why labs increasingly adopt dedicated Dermatopathology LIS solutions.
What Is a Dermatopathology LIS?
A Dermatopathology LIS is a specialized information system built to manage skin-biopsy workflows from start to finish. It integrates specimen tracking, slide imaging, case review, reporting, and quality control into a connected platform.
It unifies four key elements:
- Workflow automation
- Specimen + slide traceability
- Digital imaging and pathology review
- Diagnostic reporting + integrations
The result is a faster, more controlled, and error-resistant dermatopathology workflow.
How a Dermatopathology LIS Supports Every Stage of the Workflow

A. Specimen Collection & Accessioning
The system captures critical data including patient details, biopsy type, anatomical site, referring clinician, and description.
Key capabilities:
- Multiple-part specimen handling
- Barcode generation
- Photo capture of specimen containers
- Accurate site mapping
B. Grossing & Histology Processing
A dermatopathology LIS ensures each block and slide remains tied to the correct specimen.
Capabilities include:
- Automatic block creation
- Slide annotation and numbering
- Workflow checkpoints
- Real-time status updates
C. Digital Slide Management
Modern laboratories increasingly use digital pathology.

A dermatopathology LIS supports:
- Linking digital images to cases
- High-resolution image viewing
- Measurements and annotations
- Side-by-side comparison with previous biopsies
- Image-based alerts for missing or duplicated slides
D. Pathologist Case Review
The LIS provides structured, dermatopathology-specific templates, allowing pathologists to work faster and more consistently.
Benefits:
- Predefined diagnoses
- Synoptic reporting options
- Built-in medical terminology
- Quick-select IHC and special stains
- Smart rules to prevent incomplete reports
E. Reporting & Delivery
Once the case is finalized, the LIS formats the report and sends it to referring clinics or EMR/EHR systems.
Includes:
- PDF, text, image, and structured formats
- Automated delivery channels
- Secure clinician portal access
F. Quality Control & Auditing
Every step — from specimen receipt to report sign-off — is traceable.
Features:
- Audit trails
- Error logging
- Turnaround time metrics
- Reconciliation tools
- Peer review workflows
Dermatopathology LIS vs General LIS
| Feature / Criteria | Dermatopathology LIS | General LIS |
|---|---|---|
| Workflow Design | Built specifically for skin-biopsy workflows | Broad workflows, not specialty-specific |
| Specimen Handling | Multi-part biopsies, site-specific labeling | Standard specimen fields |
| Digital Pathology | Deep integration (WSI, annotations, comparisons) | Often optional or basic |
| Reporting Templates | Dermatopathology-focused templates | Generic AP/CP templates |
| Slide Tracking | High-precision barcode tracking | Standard slide management |
| IHC & Special Stains | Reflex stain rules + dermatopathology panels | General stain workflows |
| Case Prioritization | Designed for high-volume biopsy loads | Standard prioritization |
| Turnaround Time Analytics | Skin-biopsy TAT dashboards | Broad TAT reporting |
| Error Reduction Tools | Dermatopathology-specific QC checks | Basic QC |
| Best For | Dermatopathology labs, skin biopsy centers | General hospital / multi-discipline labs |
Benefits of Using a Dermatopathology LIS
✔️ Improved Diagnostic Speed: Automated workflows reduce delays and backlogs.
✔️ Reduced Errors: Barcode tracking & specimen validation safeguards against mix-ups.
✔️ Better Communication: Referring dermatologists receive faster, clearer reports.
✔️ Enhanced Digital Pathology Integration: Easier slide viewing, remote reporting, and telepathology.
✔️ Consistent Reporting: Standardized templates reduce variability and omissions.
✔️ Increased Productivity: Pathologists and technicians complete cases faster with fewer interruptions.
✔️ Full Traceability: Ideal for maintaining accreditation, audit trails, and compliance.
Core Features Every Dermatopathology LIS Should Have

Below are must-have features for modern dermatopathology labs:
- Multi-part specimen handling
- Advanced slide tracking
- Digital pathology integrations (scanners, viewers)
- Dermatopathology-specific reporting templates
- Reflex testing rules for IHC and special stains
- Intelligent workflow routing
- Real-time lab dashboards
- Clinician portal with case tracking
- Secure remote access for pathologists
- Scalability for high-volume labs
Future of Dermatopathology LIS: Trends to Watch
Dermatopathology is evolving rapidly. The next decade will bring:
AI-Assisted Diagnosis
Algorithms will help flag malignancies, measure margins, and prioritize cases.
Full Digital Pathology Adoption
Most labs will transition from glass slides to digital workflows.
Integrated Analytics
Labs will track performance, biopsy patterns, and diagnostic trends.
More Interoperability
Systems will communicate seamlessly with dermatology clinics, EMRs, billing software, and regional labs.
Personalized Report Formatting
Clinicians will receive adaptable, structured reports for faster interpretation.
How to Choose the Right Dermatopathology LIS

Before selecting a system, ask:
- Does it support your highest-volume workflows?
- Can it handle multiple biopsy parts with zero confusion?
- Is digital pathology supported or planned?
- Are dermatopathology templates pre-configured?
- How easy is onboarding for technicians and pathologists?
- What analytics and dashboards does it provide?
- Can the system scale as your volume grows?
A strong vendor should provide demos, sample workflows, training, and implementation support.
Conclusion
A Dermatopathology Laboratory Information System is a crucial tool for modern skin biopsy laboratories. It enhances accuracy, boosts efficiency, supports digital pathology, and ensures every case is processed smoothly from start to finish.
By choosing a solution designed specifically for dermatopathology, labs gain better control of their workflow, reduce errors, and deliver faster, more reliable results to clinicians and patients.
FAQs About Dermatopathology LIS
Q. What is a Dermatopathology LIS?
A Dermatopathology LIS is a specialized laboratory information system that manages skin-biopsy workflows from specimen accessioning to reporting, slide tracking, digital pathology, and quality control.
Q. How does a Dermatopathology LIS improve biopsy workflow?
It automates specimen handling, ensures accurate slide tracking, streamlines reporting, integrates digital images, and reduces manual errors through workflow rules and barcode-based traceability.
Q. What features should a Dermatopathology LIS include?
Key features include multi-part specimen handling, customizable dermatopathology templates, digital pathology integrations, IHC/special stain workflows, real-time dashboards, audit trails, and clinician portals.
Q. Is a Dermatopathology LIS different from a general LIS?
Yes. A general LIS manages broad lab functions, while a dermatopathology LIS is tailored for high-volume skin biopsies, digital slide workflows, specific reporting needs, and complex site-specific labeling.
Q. Who uses Dermatopathology LIS software?
Dermatopathologists, histopathology technicians, laboratory managers, dermatology clinics, multisite pathology labs, and reference laboratories handling skin biopsies use dermatopathology LIS systems.